The Mass General Brigham (MGB) Human Research Affairs Compliance and Education Office was established in June 1999 as the Human Research Quality Improvement Program within MGB Human Research Affairs which oversees human research at all MGB institutions.   The Human Research Compliance and Education Office (C&E) provides education and support to the MGB research community.  In addition, the C&E Office is required and has the authority to conduct compliance audits (routine and for cause) of human subject research studies at MGB institutions to ensure compliance with relevant federal, state, and local regulations and institutional policies.  The C&E Office is also responsible for oversight of Clinical Trials.gov registration and reporting by MGB investigators.  The C&E Office is committed